| Unit name | Molecular Pharmacology |
|---|---|
| Unit code | PHPH30029 |
| Credit points | 20 |
| Level of study | H/6 |
| Teaching block(s) |
Teaching Block 1 (weeks 1 - 12) |
| Unit director | Professor. Kelly |
| Open unit status | Not open |
| Units you must take before you take this one (pre-requisite units) |
Pharmacology of the Nervous System |
| Units you must take alongside this one (co-requisite units) |
None |
| Units you may not take alongside this one |
None |
| School/department | School of Physiology, Pharmacology & Neuroscience |
| Faculty | Faculty of Life Sciences |
Why is this unit important?
Recent advances in our understanding of the three-dimensional structure of ion channels and metabotropic receptors including G-protein-coupled receptors have significantly deepened our knowledge of the molecular mechanisms of signal transduction. These structural insights provide a crucial determinant for understanding the molecular mechanisms underlying ligand recognition and receptor activation. It provides a foundation for drug discovery. Students will study advanced topics covering the molecular pharmacology of surface expressed proteins predominantly G-protein-coupled receptors. This unit will enhance understanding of the links between ligand/protein interactions and fundamental principles of pharmacology including ligand affinity and efficacy. This will include the use of cutting-edge computational approaches for protein modelling and structure-based drug design that now play a significant role in the pharmaceutical industry.
How does this unit fit into your programme of study
This unit builds on the principles of pharmacology that you have learnt in the first two years of your programme. It will give you greater knowledge of our understanding of molecular pharmacology at the cutting edge of research required in the pharmaceutical industry. You will also increase your skill in critical analysis and data interpretation, which will support your learning in other units including your research project.
An overview of the content
You will study advanced topics encompassing molecular pharmacology. Students will finish this unit with an excellent understanding of A) advanced insights into the molecular pharmacology of drug action B) how protein structure and ligand interaction link to signalling outputs and C) the use the molecular dynamic simulations as a tool to assess drug / protein interactions. A key emphasis of this unit will be how progresses made recently in the understanding of structure–function relationships driven by computational approaches have facilitated drug development at an unprecedented pace. This unit will give students an understanding of the experimental tools that a molecular pharmacologist can use to understand drug action. The specific content of this unit will reflect the expertise in the school.
How will students, personally, be different as a result of the unit?
You will have a greater understanding of advanced aspects of molecular pharmacology and how it fits within the discipline through engaging with cutting edge research in the primary scientific literature. You will gain insight into how specific techniques are used to answer scientific questions, how to analyse and critically appraise data.
Learning Outcomes
By the end of the unit, you will be able to demonstrate:
Teaching in this unit is based on seminars. You will be encouraged to engage with the primary scientific literature and time will be given to discussion of the content of the literature and how it fits with the field of study. This will ensure that you have a good grounding in the subject and that you develop your critical analysis skills, which will support your research in other areas of the discipline and in your research project.
Tasks which help you learn and prepare you for summative tasks (formative):
Units will include an essay and a data interpretation workshop where you will have the opportunity to produce a formative piece of work to be assessed within the workshop. The workshops will enable you to become familiar with the marking criteria and how they are applied. For the data interpretation assessment, you will have the opportunity to write your answer under ‘exam conditions’. This will help you to gain experience of the timing of the exam. In the workshops you will discuss possible answers so that you can self-assess or peer assess your work, with an opportunity to discuss alternative approaches to answering the questions. As well as providing you with feedback on your work, will support the development of your critical appraisal skills. A selection of peer assessed answers will be moderated by an academic staff member.
Tasks which count towards your unit mark (summative):
The unit will be assessed through a timed assessment in the assessment preparation week and an exam in the TB1 exam period. For the timed assessment you will be expected to answer one essay question from a choice of three, which will assess your knowledge and critical understanding of the field, and your ability to gather information from the primary scientific literature. In the exam, you will be expected to answer one multi-part compulsory question assessing data handling and data interpretation skills. The timed assessment will contribute 60% of the unit mark and the exam will contribute 40%.
When assessment does not go to plan
The reassessment task will be in the same format as the main assessment, that is a timed assessment (60%) and an exam (40%). This will take place in the reassessment period.
If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.
If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. PHPH30029).
How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours
of study to complete. Your total learning time is made up of contact time, directed learning tasks,
independent learning and assessment activity.
See the University Workload statement relating to this unit for more information.
Assessment
The assessment methods listed in this unit specification are designed to enable students to demonstrate the named learning outcomes (LOs). Where a disability prevents a student from undertaking a specific method of assessment, schools will make reasonable adjustments to support a student to demonstrate the LO by an alternative method or with additional resources.
The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit.
The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates
within the Regulations and Code of Practice for Taught Programmes.
