Unit information: 3D Protein Structure and Proteomics in 2025/26

Please note: Programme and unit information may change as the relevant academic field develops. We may also make changes to the structure of programmes and assessments to improve the student experience.

Unit name 3D Protein Structure and Proteomics
Unit code BIOLM0049
Credit points 20
Level of study M/7
Teaching block(s) Teaching Block 2 (weeks 13 - 24)
Unit director Dr. Van der Kamp
Open unit status Not open
Units you must take before you take this one (pre-requisite units)

Scientific programming, Programming in R.

Units you must take alongside this one (co-requisite units)

None

Units you may not take alongside this one

N/A

School/department School of Biological Sciences
Faculty Faculty of Life Sciences

Unit Information

This unit will introduce you to the practice of applying computational approaches to analyse protein structure and function, as well as quantitative proteomics. This will include the design of analyses and use of computational tools to analyse biological structural and proteomics data. The knowledge and skills covered are relevant for the areas of structure-based drug design, functional protein design and protein engineering for medicine and biotechnology.


The aim of this unit will be to:


- Support you to acquire a detailed understanding of the concepts behind techniques for prediction, evaluation and functional annotation of protein structures, .
- Equip you with the skills required to use and interact with the types of software tools required to perform such analyses.

The unit gives you the opportunity to expand your bioinformatics skills into the identification, structural evaluation, and structure-based functional investigation of proteins.

Your learning on this unit

This unit will give you the basic understanding, expertise and practice to interpret data and design computational analyses for , and relating a protein sequence to its structure and function. This will include how to make predictions using existing data and available tools.

The following will be covered:

  • Interpreting.
  • Visualizing, evaluating and interpreting 3D protein structures.
  • Prediction of 3D structure based on protein sequence.
  • Structure-based categorization and comparison to understand protein function and evolution.
  • Prediction of how small molecules will interact with the protein structure.
  • Realizing how protein structures are not static and how their (predicted) dynamics can be linked function.


Through successful completion of the unit, you will gain the skills to integrate new software and methods into your future work, whilst retaining overall integrity of and confidence in your analyses and findings.

The Learning Outcomes (ILOs) for this unit are:

1. Employ software tools to visualize and analyse protein structures and proteomics data

2. Assess and interpret data from proteomics and protein structure databases

3. Construct logical arguments for predictions of protein function and properties from sequence

How you will learn


The unit will be delivered through online preparation material and in-person sessions that will be a mixture of short lectures followed by individual exercises with computers. Blackboard will be used to engage students with the unit content.

How you will be assessed

There will be two summative computer-based assessments. One will take place midway through the unit (20%) and one at the end (80%). The tasks in these assessments will together integrate all the learning objectives.

Resources

If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.

If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. BIOLM0049).

How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours of study to complete. Your total learning time is made up of contact time, directed learning tasks, independent learning and assessment activity.

See the University Workload statement relating to this unit for more information.

Assessment
The assessment methods listed in this unit specification are designed to enable students to demonstrate the named learning outcomes (LOs). Where a disability prevents a student from undertaking a specific method of assessment, schools will make reasonable adjustments to support a student to demonstrate the LO by an alternative method or with additional resources.

The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit. The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates within the Regulations and Code of Practice for Taught Programmes.