Unit information: Cancer Mechanisms and Genetics in 2025/26

Please note: Programme and unit information may change as the relevant academic field develops. We may also make changes to the structure of programmes and assessments to improve the student experience.

Unit name Cancer Mechanisms and Genetics
Unit code PANM30006
Credit points 20
Level of study H/6
Teaching block(s) Teaching Block 1 (weeks 1 - 12)
Unit director Professor. Anne Ridley
Open unit status Not open
Units you must take before you take this one (pre-requisite units)

None

Units you must take alongside this one (co-requisite units)

One unit from level 6/H in teaching block 1 and one level 6/H unit from teaching block 2 and Research Skills unit.

Units you may not take alongside this one

None

School/department School of Cellular and Molecular Medicine
Faculty Faculty of Life Sciences

Unit Information

Why is this unit important?

Many changes that differentiate cancer cells from normal cells occur through alterations in genes and pathways involved in normal cellular processes. This unit will cover key genes, proteins, and signalling networks that become mutated or altered in cancer, and how these changes lead to the initiation and progression of common cancers. The unit will increase students’ understanding of how cancer develops, and students will gain an appreciation of how changes in normal processes can lead to cancer. We will describe how knowledge of these genetic and epigenetic changes has been used to improve the detection and treatment of cancer.

How does this unit fit into your programme of study?

Cancer Mechanisms and Genetics builds on themes introduced in first- and second-year units such as Normal and Tumour Cells (Level 4), and Cellular and Molecular Pathology (Level 5). The Unit aims to build on this to achieve a deeper understanding of Cancer Biology, and complements the other third year cancer unit, Cancer Pathology and Therapeutics.

Your learning on this unit

An overview of content

This unit covers the following:

  • The roles of proto-oncogenes, tumour suppressors and epigenetic changes to normal processes and how they contribute to cancer development.
  • Cellular and molecular changes that occur in common cancers and how these differ depending on the cancer type.
  • Normal signalling in cell proliferation and apoptosis, and how this is changed in cancer.
  • The importance of the tumour microenvironment and inflammation in cancer progression.
  • The roles of changes to metabolism and cell-cell communication in cancer.

How will students, personally, be different as a result of the unit

Students will develop a knowledge and understanding of which key genes and signalling proteins become altered during cancer initiation and progression and give rise to major common cancers.

They will gain insight into how normal cellular and organismal processes become changed during cancer

Learning Outcomes

  • Explain the cellular and molecular changes that result in common cancers.
  • Describe the roles of changes to gene expression and metabolic pathways to cancer development.
  • Explain how normal processes such as inflammation and epithelial-mesenchymal transition contribute to cancer progression.
  • Discuss the scientific literature pertaining to cancer mechanisms and genetics and an ability to evaluate this literature critically.

How you will learn

Lectures, Data Handling Session

Independent study: Students are expected to study the recommended literature.

How you will be assessed

Task which helps you learn and prepare you for summative tasks (formative)

Students will have the opportunity to complete a formative essay on this or one of the other Level 6/H units offered by the School of Cellular and Molecular Medicine in teaching block 1. Feedback will be provided, and students will have the opportunity to familiarise themselves with the marking descriptors for the assessment criteria used at Level 6/H.

Task which counts towards your unit mark (summative)

Students will have an examination before the winter vacation. The exam consists of two essays, one chosen from each of two sections that contain three questions.

When an assessment does not go to plan.

If you are unable to take an end of unit exam due to self-certification or exceptional circumstances the faculty examination board may give you the opportunity to take this in the reassessment period. The examination will be in the same format as the initial examination.

Resources

If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.

If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. PANM30006).

How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours of study to complete. Your total learning time is made up of contact time, directed learning tasks, independent learning and assessment activity.

See the University Workload statement relating to this unit for more information.

Assessment
The assessment methods listed in this unit specification are designed to enable students to demonstrate the named learning outcomes (LOs). Where a disability prevents a student from undertaking a specific method of assessment, schools will make reasonable adjustments to support a student to demonstrate the LO by an alternative method or with additional resources.

The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit. The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates within the Regulations and Code of Practice for Taught Programmes.